Selected Publications
Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers Cai Y, Zhao P, Wu F, Zhao H, Shao H, Marra A, Patel P, O'Connell E, Fink E, Miele MM, Li Z, De Stanchina E, Cocco E, Razavi P, Toska E, Fanning SW, Xu G, Sablina AA, Scaltriti M, Chandarlapaty S.Sci Transl Med. 2025 Jun 4;17(801):eadk7786. doi: 10.1126/scitranslmed.adk7786. Epub 2025 Jun 4. Pubmed
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins Magits W, Steklov M, Jang H, Sewduth RN, Florentin A, Lechat B, Sheryazdanova A, Zhang M, Simicek M, Prag G, Nussinov R, Sablina A.EMBO J. 2024 Jul;43(14):2862-2877. doi: 10.1038/s44318-024-00146-w. Epub 2024 Jun 10.PMID: 38858602 Free PMC article Pubmed
Allosteric nanobodies to study the interactions between SOS1 and RAS Fischer B, Uchański T, Sheryazdanova A, Gonzalez S, Volkov AN, Brosens E, Zögg T, Kalichuk V, Ballet S, Versées W, Sablina AA, Pardon E, Wohlkönig A, Steyaert J.Nat Commun. 2024 Jul 23;15(1):6214. doi: 10.1038/s41467-024-50349-2.PMID: 39043660 Free PMC article Pubmed
Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer de Laat V, Topal H, Spotbeen X, Talebi A, Dehairs J, Idkowiak J, Vanderhoydonc F, Ostyn T, Zhao P, Jacquemyn M, Wölk M, Sablina A, Augustyns K, Vanden Berghe T, Roskams T, Daelemans D, Fedorova M, Topal B, Swinnen JV.Nat Commun. 2024 Oct 2;15(1):8540. doi: 10.1038/s41467-024-52978-z.PMID: 39358362 Free PMC article Pubmed
Increased dosage of wild-type KRAS protein drives KRAS-mutant lung tumorigenesis and drug resistance Tonci Ivanisevic, Wout Magits, Yan Ma, Peihua Zhao, Emiel Van Boxel, Benoit Lechat, Edward Stites, Greetje Vande Velde, Raj Sewduth, Anna Sablina bioRxiv 2024.02.27.582346; doi: https://doi.org/10.1101/2024.02.27.582346
Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor. Ivanisevic T, Steklov M, Lechat B, et al. Cancer Commun . 2023;43(12):1386-1390. doi:10.1002/cac2.12490
Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination. Sewduth RN, Carai P, Ivanisevic T, et al. Adv Sci. Published online November 9, 2023. doi:10.1002/advs.202303367
The deubiquitinase OTUB1 governs lung cancer cell fitness by modulating proteostasis of OXPHOS proteins. Sheryazdanova A, Amoedo ND, Dufour S, Impens F, Rossignol R, Sablina A. Biochim Biophys Acta Mol Basis Dis. 2023;1869(7):166767. doi:10.1016/j.bbadis.2023.166767
The regulation of the protein interaction network by monoubiquitination - Magits W, Sablina AA - Curr Opin Struct Biol. - 2022 - Pubmed
Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development - Najm P, Zhao P, Steklov M, Sewduth RN, Baietti MF, Pandolfi S, Criem N, Lechat B, Maia TM, Van Haver D, Corthout N, Eyckerman S, Impens F, Sablina AA - Cancer Res - Pubmed
Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13 - Baietti MF, Zhao P, Crowther J, Sewduth RN, De Troyer L, Debiec-Rychter M, Sablina AA - 2021 - Mol Cancer Res - Pubmed
The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers - Moens S, Zhao P, Baietti MF, Marinelli O, Van Haver D, Impens F, Floris G, Marangoni E, Neven P, Annibali D, Sablina AA, Amant F - 2021 - Sci Rep - Pubmed
Cracking the Monoubiquitin Code of Genetic Diseases - Sewduth RN, Baietti MF, Sablina AA. - 2020 - Int J Mol Sci - Pubmed
The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking - Sewduth RN, Pandolfi S, Steklov M, Sheryazdanova A, Zhao P, Criem N, Baietti MF, Lechat B, Quarck R, Impens F, Sablina AA - 2020 - Circ Res - Pubmed
Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3 - De Troyer L, Zhao P, Pastor T, Baietti MF, Barra J, Vendramin R, Dok R, Lechat B, Najm P, Van Haver D, Impens F, Leucci E, Sablina AA - 2020 - Nucleic Acids Res - Pubmed
Radiosensitization approaches for HPV-positive and HPV-negative head and neck squamous carcinomas - Dok R, Bamps M, Glorieux M, Zhao P, Sablina A, Nuyts S - 2019 - Int J Cancer - Pubmed
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination - Steklov M, Pandolfi S, Baietti MF, Batiuk A, Carai P, Najm P, Zhang M, Jang H, Renzi F, Cai Y, Abbasi Asbagh L, Pastor T, De Troyer M, Simicek M, Radaelli E, Brems H, Legius E, Tavernier J, Gevaert K, Impens F, Messiaen L, Nussinov R, Heymans S, Eyckerman S, Sablina A - 2018 - Science - Pubmed
Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism - Cai Y, Crowther J, Pastor T, Abbasi Asbagh L, Baietti MF, De Troyer M, Vazquez I, Talebi A, Renzi F, Dehairs J, Swinnen JV, Sablina A - 2016 - Cancer Cell - Pubmed
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination - Baietti MF, Simicek M, Abbasi Asbagh L, Radaelli E, Lievens S, Crowther J, Steklov M, Aushev VN, García DM, Tavernier J, Sablina A - 2016 - EMBO Molecular Medicine - Pubmed
p16INK4a Impairs Homologous Recombination-Mediated DNA Repair in Human Papillomavirus-Positive Head and Neck Tumors - Dok R, Kalev P, Van Limbergen EJ, Asbagh LA, Vázquez I, Hauben E, Sablina A, Nuyts S - 2014 - Cancer Research - Pubmed
The deubiquitinase USP33 discriminates between RalB functions in autophagy and innate immune response - Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina A - 2013 - Nature Cell Biology - Pubmed